EXCLUSIVE: Paul Bettany is in negotiations to star opposite Johnny Depp in Transcendence, the Alcon Entertainment film that marks the directing debut of Wally Pfister, Christopher Nolan’s cinematographer on Inception and many other films. Alcon partners Andrew Kosove and Broderick Johnson are producing, and Nolan and Emma Thomas are exec producers. The film was scripted by Jack Paglen and the plot is being kept under wraps. The film will start production in the spring, and Bettany will play a scientist. Warner Bros is distributing. Next up for Bettany is Iron Man 3 (he provides the voice of Tony Stark’s computer Jarvis), and he stars in the thriller Blood with Mark Strong. He was last seen in The Avengers and Margin Call. Bettany is repped by UTA, Affirmative Entertainment, and Independent Talent Group. His UK manager is 42 M&P’s Kate Buckley-Sharma.