She took over in the summer from Jill Leiderman, who ran the ABC late-night show for 14 years.
Jimmy Kimmel Live! sources confirmed Hoffman’s exit but did not disclose details.
Hoffman is a former executive producer of Entertainment Tonight and CBS Evening News‘ weekend edition.
The move comes as Kimmel returned to remote filming over the last week following a Covid-19 surge in Los Angeles. The show had resumed filming in the studio in September after Kimmel hosted the Primetime Emmys.