Little, who was finally caught and convicted of the deaths of three Los Angeles women in the late 1980s, was serving three consecutive life-without-parole sentences, the California Department of Corrections and Rehabilitation said in its announcement of his death.
An official cause of death will be determined by the Los Angeles County medical examiner’s office.
Little was the subject of the Oxygen documentary Catching A Serial Killer: Sam Little, which bowed this year on the streamer.
Little may have murdered more than the claimed 93, and law officials across the nation were trying to connect him to other unsolved cases. As of last year, they had confirmed at least 50 of his murder confessions.
Little was convicted in 2014 for the murder of the three women killed in Los Angeles in the 1980s.