Melissa George has been tapped for the lead and Brothers & Sisters alum Dave Annable for a co-starring role in NBC’s drama pilot Heart Matters. Inspired by the life of Dr. Kathy Magliato, the medical soap follows the outspoken Alex Panttiere (George), one of the rare female heart-transplant surgeons. Alex brings an innovative eye to treating patients week to week while also balancing the complications of her professional and romantic life. Annable, repped by CAA and Barking Dog Entertainment, plays Alex’s boyfriend. He most recently co-starred on Fox’s Red Band Society.