She took over in the summer from Jill Leiderman, who ran the ABC late-night show for 14 years.
Jimmy Kimmel Live! sources confirmed Hoffman’s exit but did not disclose details.
Hoffman is a former executive producer of Entertainment Tonight and CBS Evening News‘ weekend edition.
The move comes as Kimmel returned to remote filming over the last week following a Covid-19 surge in Los Angeles. The show had resumed filming in the studio in September after Kimmel hosted the Primetime Emmys.
Subscribe to Deadline Breaking News Alerts and keep your inbox happy.