Laura Linney and Cynthia Nixon are set to topline the Manhattan Theatre Club’s revival of The Little Foxes — with a twist: The veteran actresses will trade off playing the lead roles. Daniel Sullivan will direct the repertory production of Lillian Hellman’s play, which begins previews March 29 for an April 19 opening at the Samuel J. Friedman Theatre.

The show’s fourth revival — and first since 1997, with Stockard Channing and Frances Conroy — will see Linney and Nixon alternating as  Regina Hubbard Giddens and Birdie Hubbard, both part embers of a strong-willed aristocratic Southern family. The switchoff will be a first for MTC, and the schedule of who will play which role and when will be released in the spring. Set in 1900 Alabama, The Little Foxes follows Regina Giddens and her ruthless clan, including her sister-in-law Birdie, as they clash in often brutal ways in an effort to strike the deal of their lives.

Frequent MTC collaborator Sullivan, a Tony winner for 2001’s Proof, directed Linney to Tony noms for a pair of plays Sight Unseen (2005) and Time Stands Still (2010), the latter being her most recent Main Stem turn. He also helmed 2006’s Rabbit Hole, for which Nixon won a Tony.