The new title makes perfect sense. Written by Crisis and Life creator Rand Ravich and executive produced by Howard Gordon, Second Chance centers on Jimmy Pritchard, a 75-year-old disgraced ex-sheriff whose life ends at the hands of corrupt cops. He is brought back to life and given a second chance by a pair of young tech scientists as a 35-year-old (Rob Kazinsky) with unpredictable near-superhuman abilities. The name of the company of the two scientists, twins Otto (Adhir Kalyan) and Mary (Dilshad Vadsaria), is Lookinglass (which explained the second title change).
The first name change was made because the producers wanted to distance themselves from the famous Frankenstein moniker, stressing that the series only takes inspiration from the basic Mary Shelley mythology of a man brought back to life by scientists playing God.