The Deuce is written and executive produced by Simon and George Pelecanos, and directed by Michelle MacLaren (Breaking Bad), who also exec produces with Nina K. Noble and Richard Price. Marc Henry Johnson, who was instrumental in documenting the story, is a producer.

Levieva, repped by UTA and Silver Lining Entertainment, was recently seen in the features The Diary of a Teenage Girl and Sleeping with Other People. Gilliard is repped by Innovate Artists and Thruline Entertainment; Fishback is with Don Buchwald & Associates and Schreck Rose.