“When life falls apart, friends keep it together.” Here’s the first trailer for Miss You Already, starring Toni Collette and Drew Barrymore in a tale of best-friendship and life’s roughest moments. Milly and Jess have been inseparable since childhood. They’ve done lots of crazy stuff, but bonds are tested when one faces a life-threatening disease and the other has a life-affirming pregnancy.

Dominic Cooper, Paddy Considine, Frances de la Tour and Jacqueline Bisset co-star in the film from Twilight director Catherine Hardwicke. British writer-actress Morwenna Banks wrote the script. Miss You Already will have its world premiere September 12 at the Toronto Film Festival, followed by a limited theatrical release November 6.