Emmy-winning The Powerpuff Girls is coming back. Cartoon Network said today it is rebooting the uber-successful franchise with an all-new television series produced by Cartoon Network Studios and a full licensing program that will roll out across all regions. It’s slated for a 2016 launch. “The original Powerpuff Girls was a franchise phenomenon for Cartoon Network, paving the way for a new generation of innovative storytellers and enthusiastic fans worldwide,” said Rob Sorcher, Cartoon Network’s chief content officer. “We are calling these girls back into action based upon an overwhelming demand for sugar, spice and Chemical X.”

The Powerpuff Girls is one of the top-grossing Cartoon Network brands of all time, with more than $2.5 billion in retail sales generated since its debut in 1998. Created by Craig McCracken, the show revolved around three sugar-coated superheroes whose mission in life alternates between going to school, fighting crime and winning at hopscotch. It earned two Emmys and five noms, along with numerous animation honors throughout its 78-episode run. The series also inspired a 2003 feature film, a 10th anniversary special and a re-imagined CG special, The Powerpuff Girls: Dance Pantsed, which aired on Cartoon Network in January and featured Ringo Starr.