In her return to television, Desperate Housewives star Marcia Cross is taking a comedy route, signing on for the lead female role in Fox‘s single-camera comedy pilot Fatrick. The project, written by Don’t Trust The B—- In Apt. 23 creator/executive producer Nahnatchka Khan and co-exec producer Corey Nickerson and to be directed by Oscar-winning scribes Nat Faxon & Jim Rash, centers on Patrick, a 30-something moving man and former fat kid, who, realizing that his life isn’t quite where it should be, is forced to face the damage caused by years of being “Fatrick”: a chubby little kid just trying to survive. It will be shifting between the present and Patrick’s school years. Cross will play Patrick’s mother Arlene, seen in both present day and flashback. A fit, energetic nutritionist, she is rigid and intense when it comes to her family’s eating habits. Cross joins recently cast Ray Ford. This marks the biggest half-hour commitment for Cross, who had largely done drama series before her turn in the comedic one-hour Desperate Housewives. She took a break after the end of the ABC series to spend time with her twin girls, born while Cross was on the show, and is now making her return to TV. She is with Gersh and Gartner/Green Entertainment.