EXCLUSIVE: Academy Award-nominated John Lithgow will star alongside Alfred Molina in Ira SachsLove Is Strange, the NYC-set drama about a just-married gay couple whose honeymoon is complicated when circumstances force them to temporarily separate. When George (Molina) loses his job, his partner of 38 years, painter Ben (Lithgow), moves in with his nephew and George with the gay cops next door. Michael Gambon was initially set to play the role of Ben before scheduling conflicts led to his departure from the project. It’s the next pic from Sachs after 2012’s award-winning Keep The Lights On and the first collaboration by longtime pals Lithgow and Molina. “We’ll be playing the main roles in the best script I’ve read in years,” said Lithgow in a statement, “a vivid portrait of marriage, with all its joy, folly, and occasional heartbreak.” Filming is set for August in NYC.

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Lithgow is coming off of the Tommy Lee Jones-directed prairie drama The Homesman with Jones, Hilary Swank, and Meryl Streep, and is set to appear in Christopher Nolan’s Interstellar. The Tony and Emmy winner is repped by WME, who also rep Molina. Love is Strange is produced by Sachs with Parts & Labor’s Lars Knudsen and Jay Van Hoy, Lucas Joaquin, and Jayne Baron Sherman. Sachs co-scripted the pic with Mauricio Zacharias. Fortissimo Films is repping international sales.