EXCLUSIVE: Naomi Watts is in talks to star in St. Vincent De Van Nuys, the film that Ted Melfi will direct from his script for The Weinstein Company, Chernin Entertainment and Don Cheadle’s Crescendo. Watts will join Bill Murray, Melissa McCarthy and Chris O’Dowd. Watts will play a Russian prostitute who develops a close relationship with the title character (Murray), a cantankerous guy who becomes a chief influence on an angelic 12-year old boy whose hardworking single mother (McCarthy) foists child care duties on Murray’s character. The project, which Chernin Entertainment developed for two years with Melfi’s Black List script, has been compared to As Good As It Gets or even TWC’s recent Silver Linings Playbook for the way it mixes comedy and human pathos. Watts is coming off an Oscar-nominated performance in The Impossible. Every age appropriate hot actress in town chased this role. She’s repped by CAA and Untitled.