EXCLUSIVE: Jeanne Tripplehorn and Patricia Clarkson are set to star in the Lifetime original movie Project Five, an anthology of five short films exploring the impact of breast cancer on people’s lives, four of which are being directed by Jennifer Aniston, Alicia Keys, Demi Moore and Patty Jenkins. Tripplehorn plays Pearl, the only character, an oncologist, who appears in all five segments. Her main film is directed by Jenkins. Clarkson will star in the segment directed by Aniston. Project Five, from Sony TV and exec producers  Aniston, Marta Kauffman, Paula Wagner, Kristin Hahn, Kevin Chinoy and Francesca Silvestri, is slated to air in October, which is breast cancer awareness month.

Newcomer Alice St. Clair has been tapped to play Kate Middleton in Hallmark’s movie William and Kate: A Royal Love Story. The biopic of the glamorous future royal couple was written by and is executive produced by Emmy-winning producer Linda Yellen, who also exec produced the hugely popular telefilm The Royal Romance of Charles and Diana, about the once-fairytale love story of Prince William’s parents. Filming is scheduled to begin May 9 in Bucharest for an Aug. 13 premiere. British actress St. Clair is repped by Gersh and TMT Entertainment. Lifetime’s William & Kate, which stars Nico Evers-Swindell as Prince William and Camilla Luddington as Middleton, premieres next Monday.