In her first regular comedy gig, Eliza Dushku is set as the female lead opposite Damon Wayans in CBS’ untitled sports radio show pilot. The multicamera comedy, from veteran writer-producers Bill Martin and Mike Schiff, is inspired by ESPN personality Colin Cowherd’s outspoken sports talk show. It centers on Nick (Wayans), an egotistical sports-radio host with a quick wit and cocky likability who is adored by his fans. Dushku will play Nick’s radio cohort Casey, a fun, quick-witted gal who is socially oblivious and pathologically blunt. Dushku, repped by UTA and The Collective, is best known for her roles on dramas Buffy the Vampire Slayer, Tru Calling and Dollhouse. She recently guest starred on another CBS multicamera comedy, The Big Bang Theory.

David Alpay (The Tudors) is set to co-star opposite Lauren Ambrose in Fox’s drama pilot Weekends at Bellevue. Based on Julie Holland’s memoir, Bellevue centers on Ellie (Ambrose), the psychiatrist in charge of the weekend shift at Bellevue Hospital’s psychiatric unit. Alpay, repped by APA and KLWG, will play Ben, a second-year attending psychiatrist at Bellevue who graduated from an Ivy League school and comes from a family of doctors. He has a history with Ellie and is strongly drawn to her.

Tricia O’Kelley (The New Adventures of Old Christine) has joined another CBS comedy pilot, the untitled Filgos project, which centers on a blue-collar guy who wrestles with how to parent his unmarried grown daughter Eileen (Becki Newton) and her 12-year-old son while sharing a house with them as well as his wife and recently widowed mother. O’Kelley, repped by Domain and Art/Work, will play Eileen’s older sister, who’s happily married with two unproblematic kids.

Smith Cho (Ugly Betty) has landed a lead in NBC’s comedy pilot Lovelives. The multi-camera comedy revolves around married couple Tim (Ryan Hansen) and Holly (Amanda Loncar) who, along with Tim’s siblings Blake (Sean Maguire) and Maddie, and Blake’s sarcastic ex-wife Kate (Cho), navigate the twists and turns of love in New York City.

Audrey Esparza has been added to NBC’s untitled Dan Goor pilot. The multicamera comedy, from writer/exec producer Dan Goor, centers on Adam Foote (Andrew J. West), a young doctor who joins his parents’ medical practice and spends as much time tending to his family as to his patients. Esparza, repped by Innovative and ATA Management, will play a kind-hearted RN at the family clinic. She tries to be especially helpful to the recently returned Adam, who seems like he might be romantically interested in her.