Kenneth Kleinberg, who built his five-decade Hollywood practice lawyering the likes of Jack Nicholson, J.K. Rowling, Johnny Depp and Toby Keith among many others, co-founded the University Kidney Research Organization after his own fight with kidney disease. Its stem cell-based research has led to the development of a synthetic kidney its makers believe will be ready for transplants inside of a decade. “If this is successful…it’ll be one of the biggest medical breakthroughs ever, on par with the Salk vaccine for polio,” he says.