EXCLUSIVE: Lauren Ambrose has been tapped to play the female lead in TNT’s high-profile pilot Monsters Of God. She will co-star alongside Garret Dillahunt in the period drama set in post-Civil War Texas. Rod Lurie is writing, directing and executive produces with his Battle Plan Productions partner Marc Frydman and Plan B Entertainment’s Dede Gardner, Jeremy Kleiner and Sarah Esberg.

Ambrose, the two-time Emmy nominee for Six Feet Under, will play Cynthia Lancaster, wife to Dillahunt’s Col. “Terrible” Bill Lancaster, who despite the peace between the Comanche and locals sets sets out on a quest to kill off every single member of the tribe, bringing wild chaos to the town of Slater. Cynthia, meanwhile, will let no one get in the way of her obsessive quest to institute her wildly feminist ideals. Cultured, strategic and ferociously ambitious, she’ll go to great lengths to show that she is not defined by her role as Bill’s wife. She has an agenda that often conflicts with her husband and has the potential to radically redefine the frontier culture they live inside.

Ambrose most recently toplined Amazon’s pilot The Interestings, the drama adapted from Meg Wolitzer’s bestseller and directed by Mike Newell that ended up not going forward. She is repped by UTA, Kipperman Management and Sloane Offer.