Sandra Bullock will kick off premiere week for Harry, Harry Connick Jr.’s new syndicated daytime talk show that premieres on September 12. Renee Zellweger, Amy Adams, and Empire star Terrence Howard round out the premiere week guests with cameos by Russell Crowe, Kristen Bell, Zooey Deschanel, Anthony Anderson, John Stamos and Taraji P. Henson.

Week two kicks off with a daytime exclusive from the set of Empire and a behind-the-scenes look at the hit show.

Harry will include comedic segments, man-on-the-street interviews, as well as audience participation, human interest stories and celebrity interviews. The show also will celebrate unsung everyday heroes in signature segments like “Harry’s Leading Ladies” and “I Got This.