HBO has picked up Room 104, an anthology comedy series from brothers Jay and Mark Duplass. Set in a single room of an average American hotel, Room 104 tells a different story of the assorted characters who pass through it in each episode. It will begin production in Los Angeles later this year for 2017 debut.

“Jay and Mark Duplass are two of the most inventive talents in TV today,” said HBO president of programming Casey Bloys. “We’re excited to see what they do with this unique concept.”

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The project stems from filmmaking brothers Jay and Mark Duplass’ overall deal with HBO. The duo (along with Steve Zissis) also created the HBO comedy series Togetherness, which ran for two seasons, and executive produce HBO’s adult animated comedy series Animals, which returns for its second season in 2017.

“We’ve all seen stories set in seedy motels and high-class international resorts, but for years we’ve been fascinated by the funny, weird, sad, scary, absurd things going down in that corporate chain hotel near the airport. That’s what Room 104 is after… finding some magic in the seemingly mundane,” said Jay and Mark Duplass.

Room 104 will be executive produced by Jay & Mark Duplass, who are also showrunners; executive producer, Xan Aranda; producer, Sydney Fleischmann.

The Duplasses are repped by ICM Partners and Sloane Offer.