The Grinder alum Rob Lowe has joined the cast of CBS medical drama Code Black as a series regular. His character will be introduced in the Season 2 premiere on September 28.

Lowe will play Col. Ethan Willis, a doctor in the U.S. military’s prestigious Combat Casualty Care research program who has been pulled out of a combat hospital in Afghanistan and embedded at Angels Memorial to teach what the military has learned about combat medicine. His aggressive, rule-breaking style is greeted enthusiastically by Dr. Leanne Rorish (Marcia Gay Harden) but not by all the other doctors. In addition to Harden, he’ll join Code Black stars Luis Guzman, Melanie Chandra, Harry Ford, Benjamin Hollingsworth, Jillian Murray, Boris Kodjoe and William Allen Young.

Lowe received a Golden Globe nomination earlier this year for his starring role in Fox’s now-canceled comedy The Grinder. His starring role in hit TV drama series The West Wing also earned him an Emmy nom and two Golden Globe nominations. His other TV credits include Parks and Recreation, Brothers and Sisters, a starring role in the TV movie Killing Kennedy and a co-starring role in Emmy-winning Behind the Candelabra, for which he also received a Golden Globe nom. On the film side, Lowe will be seen alongside Kristen Bell, Raquel Welch, Rob Riggle and Eugenio Derbez in upcoming comedy feature How to Be a Latin Lover for Lionsgate’s Pantelion label and Monster Trucks, set for release in 2017.

The addition of Lowe is part of other Season 2 changes at Code Black, and comes on the heels of the castings announced Friday of Noah Gray-Cabey, Emily Tyra and Nafessa Williams in recurring roles. All are helping to fill the vacancies left by Bonnie Somerville (Christa) and Raza Jaffrey (Neal) who exited the series.