Disney and Selma director Ava DuVernay are setting Oprah Winfrey to star in A Wrinkle In Time, an adaptation of the 1963 Newbery Medal-winning Madeleine L’Engle fantasy classic novel that has a script by Oscar-winning Frozen writer and co-director Jennifer Lee. Winfrey will play the role of Mrs. Which. The studio is moving quickly to cast the film, with actors including Amy Adams and Kevin Hart chief among those circling. Winfrey is in final negotiations. She starred for DuVernay in Selma and played a role behind the scenes in helping to make the movie happen. Winfrey and DuVernay also co-created and are exec producing the upcoming OWN series Queen Sugar.

This is a big one for Disney Motion Pictures president Sean Bailey and exec Tendo Nagenda, who’s steering the film. A Wrinkle In Time involves a young girl whose government scientist father has gone missing after working on a mysterious project called a tesseract, which involves being transported to a fifth dimension with mysterious inhabited planets. She takes part in a search for her father and sees some incredible creatures along the way.

Winfrey is repped by WME.