Camryn Manheim (Person of Interest, The Practice), Eric Roberts (The Dark Knight, CSI: Crime Scene Investigation) and Alexandra Grey (Transparent, When We Rise) are set to guest star in the second season of CBS medical drama series Code BlackThe three will appear in an episode titled “Life and Limb.”

Manheim will play Alice, the emotionally distraught wife of a truck driver who is injured in a horrific accident. Roberts will portray Vince Savetti, Mario’s (Ben Hollingsworth) opportunistic, but sympathetic father who tries to hustle his son into an investment. Grey is a transgender actress who will play the role of Beth, a strong, confident transgender woman. When stomach pains send her to the ER, she is forced to confront her past.

Code Black has been undergoing creative changes for Season 2 and a structure resembling real-life that includes a revolving cast of younger cast members. The series, whose first season revolved around four first-year residents and their colleagues at the fictional Angels Memorial Hospital, was a consistent ratings performer, never falling under 1.1 ratings among adults 18-49 in Live+same day.

Code Black returns in the fall in its Wednesday 10 PM time slot.