EXCLUSIVE: Agents of S.H.I.E.L.D. alumna Adrianne Palicki is set as the female lead opposite Seth MacFarlane in his 13-episode straight-to-series hourlong comedic drama for Fox. Also cast in the project is longtime MacFarlane voice actor Scott Grimes.

Set 300 years in the future, the untitled show — MacFarlane’s first live-action TV series — follows the adventures of the Orville, a not-so-top-of-the-line exploratory ship in Earth’s interstellar fleet. Facing cosmic challenges from without and within, this motley crew of space explorers will boldly go where no comedic drama has gone before.

Scott Grimes
Associated Press

MacFarlane plays Ed, captain of Orville. Palicki plays Kelly Grayson, Ed’s ex-wife and the newly appointed First Officer of the Orville. Grimes plays Gordon, Ed’s best friend whom he hires to pilot the Orville.

Palicki is coming off a two-season stint on ABC’s Agents of S.H.I.E.L.D, where she played fan favorite Bobbi Morse. Along with Nick Blood, she also toplined the spinoff pilot Marvel’s Most Wanted this past season. In features, she recently co-starred in John Wick. The Friday Night Lights alumna is repped by WME, Anonymous Content and attorney David Fox.

Grimes has been acting alongside MacFarlane for more than a decade on MacFarlane’s animated comedy American Dad, where Grimes is a main cast member, voicing the son of MacFarlane’s Stan. Grimes also has done voice work on MacFarlane’s flagship animated comedy Family Guy. Grimes, who recurred on Justified, is repped by Abrams and Industry Entertainment.