Whitney Cummings will star in and make her directing debut with The Female Brain, a relationship comedy she co-wrote with Neal Brennan. Based on Louann Brizendine’s nonfiction book, the film looks at couples who demonstrate the workings of primal neurology in their romantic relationships. Black Bicycle Entertainment is financing and Erika Olde will produce alongside Michael Roiff of Night and Day Pictures. Casting is underway, with principal photography set to begin in July in Los Angeles.

The Female Brain book coverThe Female Brain is a book that profoundly changed my life, and I’m really proud of how Neal Brennan and I wrote the script in a way that addresses how both men and women are often challenged and undermined by their reptilian brains and primordial fears,” Cummings said. “I’m really grateful Black Bicycle is letting me make a science comedy.”

Stand-up veteran Cummings created and starred in the 2011-12 NBC comedy Whitney and created CBS’ 2 Broke Girls, which launches its sixth season in the fall. She recently did stand-up specials for HBO and Comedy Central and is filming a role in Warner Bros’ Unforgettable opposite Katherine Heigl and Rosario Dawson. She is repped by CAA, which is handling The Female Brain‘s world rights, and Mosaic.