Well before the Chicago Fire spinoff’s November premiere, NBC’s upcoming Chicago Med has lost one of the main cast as The Walking Dead alum Laurie Holden has departed from the show. “I am so grateful to Dick Wolf, my fellow cast members, NBC and the entire Chicago Med team for their understanding,” Holden said in a statement. “Sometimes we must make tough choices and, for family reasons, not doing Chicago Med is one of those for me at this time. I know the show is going to be a huge success and I’ll be watching.” Holden’s departure occurred just prior to TCA, though only now has become the subject of discussion.

“It was Laurie’s decision to opt out of the series,” a spokesman for the series said in a statement. “We are sorry to see her go. We are currently casting additional new roles which we hope to have confirmed very soon.”

Holden appeared in the show’s Chicago Fire backdoor pilot back in April, in the role of troubled ER surgeon Dr. Hannah Tramble. She won’t be recast, and instead, three new female roles will be added: an emergency pediatrician, a charge nurse, and a young first year resident.

The second spinoff of Chicago Fire, following Chicago PD, Chicago Med premieres Tuesday, Nov. 10 at 10 p.m. on NBC. The show stars Oliver Platt, S. Epatha Merkerson, Nick Gehlfuss, Yaya DaCosta, Colin Donnell and Brian Tee.