James Lesure (Men At Work) is set to co-star opposite Mike Epps in Uncle Buck, ABC‘s single-camera comedy pilot based on the classic John Hughes film starring John Candy. Like the movie, the series adaptation, written by Steven Cragg and Brian Bradley, centers on Buck Russell (Epps), a childish man who learns how to be an adult by taking care of the kids of his younger yet more accomplished brother Will (Lesure) in a very childish way. Nia Long plays Will’s wife in the project from Universal TV and Will Packer Prods. Cragg, Bradley and Packer executive produce the pilot, with Korin Huggins co-executive producing. Lesure is managed by Vince Circionne.

millsJLouis Mills has booked a regular role in NBC’s drama pilot Heart Matters. The medical soap follows the outspoken Alex Panttiere (Melissa George), one of the rare female heart-transplant surgeons. Alex brings an innovative eye to treating patients week to week while also balancing the complications of her professional and romantic life. Mills will play Dr. Forrester, who was left with a nasty scar and one arm by the war in Iraq. The actor, who was left blind in his left eye following a botched cataract surgery, marks the first pilot booking for KMR’s recently launched Diversity Department that handles performers with disabilities.