EXCLUSIVE: Stanley Tucci has contracted for the villain role in Screen Gems’ Patient Zero, starring opposite Natalie Dormer and Matt Smith. Stefan Ruzowitzky is directing the Mike Le-scripted action thriller, and Vincent Newman is producing.

In Patient Zero, an unprecedented global pandemic of a super strain of rabies has resulted in the evolution of a new species driven by violence. An inexplicably immune human survivor with the ability to communicate with this new species must spearhead a hunt for Patient Zero in order to find a cure to save his infected wife and humanity.

Tucci plays a deliciously evil role: a professor who becomes infected, and highly violent. He becomes determined to crash the lab that’s working on a cure and thwart the search for Patient Zero. He previously starred in the Screen Gems pics Easy A and Burlesque.