Carlton Cuse’s alien invasion-themed USA pilot Colony has brought together alums from two of the biggest genre series of the Past decade, with The Walking Dead‘s Sarah Wayne Callies set as female lead opposite Lost‘s Josh Holloway.

Colonyusa-network, co-written by Lost co-showrunner Carlton Cuse and Ryan Condal and directed by Juan José Campanella, is a family drama/thriller about life in Los Angeles after a mysterious “foreign” occupation. It centers on Will Bowman (Holloway), a former FBI agent who — to protect his family — is forced to collaborate with the occupational government to bring down the growing resistance movement inside the Los Angeles colony. Callies will play Will’s wife, Katie Bowman, a mother of three who faces a daily struggle to keep her family safe and united in an occupied L.A.

Colony is a co-production between Legendary Television and Universal Cable Prods. Before her stint on Walking Dead, Callies co-starred on Fox’s Prison Break. She is shooting the feature film Pay The Ghost opposite Nicolas Cage and recently wrapped The Other Side Of The Door. She is repped by More/Medavoy and Sloane Weber.