Showtime said today that it is ending its hospital dramedy that stars Edie Falco as a duplicitous, pill-popping ER nurse and mom. Nurse Jackie will hang up the stethoscopes after the upcoming seventh season, which was ordered in March and saw production Image (2) nursejackie__140331161950-275x369.png for post 707022begin this week. It’s the premium cable net’s longest-running current comedy and among it highest rated. Falco won an Emmy in 2010 for her title role as Jackie Peyton, making her the only woman to win lead acting Emmys for a comedy and drama, following her three wins for HBO’s The Sopranos.

“Edie is one of our finest actresses,” Showtime Networks President David Nevins said in a statement. “She creates indelible characters, and Nurse Jackie Peyton is no exception.  I know this final season will bring her story to a close that will satisfy the ever-growing number of loyal viewers who have been entranced and, at times, appalled by Jackie through the years.”

Set mostly at fictional All Saints Hospital in Manhattan, the series got a best comedy Emmy nom in 2010, and Merritt Wever snagged the supporting actress statuette last year for her role as  the maddeningly cheerful nurse Zoey Barkow. The cast also Image (3) Nurse-JAckie__130625025053-275x150.jpg for post 528068includes Peter Facinelli, Paul Schulze, Dominic Fumusa, Anna Deavere Smith, Stephen Wallem, Betty Gilpin, Ruby Jerins and Mackenzie Aladjem. Multiple Emmy winner Tony Shalhoub (Monk) will guest on the coming season as Bernard Prince, a new ER doctor who has a great bedside manner, a special touch with the boss and who offers Jackie something she desperately needs: a friend.

Nurse Jackie survived a major behind-the-scenes shakeup after Season 4 when co-creators/showrunners Linda Wallem and Liz Brixius left. With Clyde Phillips at the helm, the series went on for three more seasons.

“It is with great sadness and pride that we and Showtime bid farewell to such an outstanding series like Nurse Jackie, its stellar cast led by the incomparable Edie Falco, brilliant producing team led by Clyde Phillips and Richie Jackson, and the entire Nurse Jackie family of craftspeople and artists that bring this show to rapt audiences year after year,” said Kevin Beggs, Chairman of Lionsgate Television, which produces the show with Showtime. “We consider ourselves lucky to have been part of the Nurse Jackie story and look forward to an unforgettable final season.”