Steven Soderbergh directs and Clive Owen stars in Cinemax‘s new 10-part series The Knick, slated to debut August 8. Set in downtown New York in 1900, The Knick centers on Knickerbocker Hospital and the groundbreaking surgeons, nurses and staff who push the bounds of medicine in a time of astonishingly high mortality rates and zero antibiotics. André Holland, Eve Hewson, Juliet Rylance, Jeremy Bobb, Michael Angarano, Chris Sullivan, Cara Seymour, Eric Johnson, David Fierro, Maya Kazan, Grainger Hines, Leon Addison Brown and Matt Frewer round out the ensemble cast. Check out the first trailer.