Samantha Mathis has been cast in AMC‘s pilot Line Of Sight, from creator Blake Masters and director Jonathan Demme. It tells the story of Lewis Bernt (David Morrissey), a National Transportation Safety Board investigator who survives a mysterious plane crash, bringing him on an emotionally disorienting quest to discover the accident’s cause. Mathis, repped by Paradigm and the Schiff Co, will play Tony’s (Kai Lennox) wife. She comes off a recurring role on CBS’ breakout Under The Dome.

Canadian actress Natalie Brown (Being Human) has booked the FX pilot The Strain, directed by Guillermo del Toro. It tells the story of Dr. Ephraim Goodweather (Corey Stoll), the head of the Centers for Disease Control Canary Team who are called upon to investigate a mysterious viral outbreak with hallmarks of an ancient and evil strain of vampirism. Brown will play Eph’s ex-wife Kelly Goodweather fails to heed her husband’s warning about the contagion spreading in Manhattan. She replaces Lauren Lee Smith who was originally cast in the role. Brown, repped by Thruline and Amanda Rosenthal Talent, recurs on Canadian series Cracked and Bitten.

In other pilot castings, Constance Wu (Covert Affairs) has been cast in Bryan Fuller’s 90-minute Syfy pilot High Moon, which explores what happens when the countries of Earth establish colonies to mine the moon’s resources and discover a new form of life. Wu, repped by TalentWorks and Generate, will play the recurring role of Mikiko, the technically savvy and sole living being in the otherwise fully automated Japanese base.