EXCLUSIVE: Andre Holland (42), Juliet Rylance (Sinister), Eve Hewson (Enough Said) and Michael Angarano (Empire State) are set to co-star opposite Clive Owen in Cinemax‘s 10-part series The Knick, directed by Steven Soderbergh. Oscar winner Soderbergh is set to direct all 10 episodes of the project, written by Jack Amiel and Michael Begler. Set in downtown New York in 1900, The Knick centers on Knickerbocker Hospital and the groundbreaking surgeons, nurses and staff who push the bounds of medicine in a time of astonishingly high mortality rates and zero antibiotics. Holland, repped by Paradigm and Brookside Artist Management, will play Algernon, a gifted, black Harvard-trained surgeon who fights for respect in the hospital while trying to navigate his way through the racially charged turn-of-the-century NYC. Rylance will play Cornelia, a driving force whose passionate social work at The Knick will always play second fiddle to her wealthy father’s philanthropy toward it. Hewson will play Lucy, a young, naive nurse from the South who, like tens-of-thousands of others, has come to New York for adventure and finds more of it than she ever thought she would. Angarano will play Dr. Bertram “Bertie” Chickering Jr., an eager surgeon-in-training who gives up the chance to practice uptown in a wealthy hospital, for the romance and excitement of learning from a groundbreaking surgeon in the chaotic, downtown world of The Knick. Production is set to begin in New York in late September. Amiel, Begler, Soderbergh, Owen, Michael Sugar and Gregory Jacobs executive produce.