EXCLUSIVE: One of the longest-running relationships between an actress and her manager has just come to an end. I’ve confirmed that Reese Witherspoon has exited Management 360. That ends the 19-year long run between the Oscar-winning actress and her manager Evelyn O’Neill. I haven’t heard a specific reason for the exit, but it has to be a tough day for the founding partner of Management 360, who guided Witherspoon’s career since she was a teenager. The split is amicable, per both sides. Witherspoon’s star power was at its highest when she headlined comedies like Legally Blonde and Sweet Home Alabama and won her Oscar for 2005’s Walk The Line, but she has been doing fine as an actress and producer. She most recently starred in the Jeff Nichols-directed Mud and has the Atom Egoyan-directed Devil’s Knot opening in Toronto. She next stars in The Good Lie and Paul Thomas Anderson’s Inherent Vice. She’s also a producer on numerous projects including Gone Girl, which is David Fincher’s next film with Ben Affleck starring.

Witherspoon remains with CAA. Said O’Neill: “The time has come for us to go our separate ways after 19 years. I am so proud of her career and everything we accomplished together.” O’Neill continues to rep clients that include Julianne Moore, Salma Hayek, 42‘s Chadwick Boseman, Zach Braff, Bryce Dallas Howard, Greta Gerwig, Miley Cyrus, Justin Bartha and Michael Chiklis.