In the hours before Hurricane Sandy, Jimmy Fallon opens the show from the deserted NYC streets, then performs his monologue for an empty audience:

Hurricane Sandy: Problems Extend Into Tuesday
‘Letterman’ EP Says Tonight’s Show “Bizarre And Beautiful”: Video

4 years
Being the number one network is not a high bar?
Comedy Lover
4 years
I thought it was hilarious. One for the archive for sure. It's comedy, people. Don't be so...
4 years
If you watched the show, you'd know the entire crew was given the option to go home,...